Authors lament the unmet promise of a miracle drug for Alzheimer disease but are heartened by what they see as encouraging improvements in care (care transformation) for a growing population of older adults, many with dementia. read the full article

One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' now provides a 3D view of brain molecules with 10 times greater detail. This imaging technique could help reveal how the disease...

Researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in the brain linked to synapses, has the potential to accelerate research...

An analysis of information gathered for an ongoing and federally sponsored study of aging and disability adds to evidence that a substantial majority of older adults with probable dementia in the United States have never been professionally diagnosed or are unaware...

According to the Centers for Disease Control and Prevention, an estimated 1 out of 3 American adults live with higher than normal blood sugar levels known as prediabetes. Researchers recently found that while men may lose more weight on low-carb diets, women actually...

A new discovery in how heart muscles maintain their shape in fruit flies sheds light on the crucial relationship between cardiac function, metabolism, and longevity. Researchers have discovered that maintaining high levels of the protein vinculin confers health...

In adults over 70, exposure to general anesthesia and surgery is associated with a subtle decline in memory and thinking skills, according to new research. The study analyzed nearly 2,000 people and found that exposure to anesthesia after age 70 was linked to...

Ultrasound waves applied to the whole brain improve cognitive dysfunction in mice with conditions simulating vascular dementia and Alzheimer's disease. It is possible that this type of therapy may also benefit humans. read the full article

Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks. When the mitochondrial...

Journal of the American Geriatrics Society Research Summary Heart failure affects more than 6 million people in the U.S.—most of whom are older adults. Roughly half the older adults who have heart failure also live with five or more other chronic health conditions....